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Development of the IFNγ-driven sepsis (IDS) endotype in the discovery set . A) Bar graphs of 28-day mortality in patients with IFNγ more than 3 pg/ml and IFNγ 3 pg/ml or less. The p-value of comparison by the Fisher's exact test is provided. B) Distributions of the absolute count of HLA-DR receptors on CD45/CD14-monocytes in patients with IFNγ more than 3 pg/ml and IFNγ 3 pg/ml or less. Lines overlying the distributions represent medians and interquartile ranges. The p-value of comparison by the Mann–Whitney U test is provided. C) Distributions of <t>sCD163</t> in patients with IFNγ more than 3 pg/ml and IFNγ 3 pg/ml or less. Lines overlying the distributions represent medians and interquartile ranges. The p-value of comparison by the Mann–Whitney U test is provided. D) Distributions of CXCL9 in survivors and non-survivors. This comparison involves only the patients with IFNγ levels more than 3 pg/ml. Lines overlying the distributions represent medians and interquartile ranges. The p-value of comparison by the Mann–Whitney U test is provided. Abbreviations: CI, confidence interval; IDS, IFNγ-driven sepsis; IFN, interferon; n, number of patients.
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Characteristics of patients according to the antiretroviral regimen composition

Journal: Journal of Antimicrobial Chemotherapy

Article Title: No accelerated progression of subclinical atherosclerosis with integrase strand transfer inhibitors compared to non-nucleoside reverse transcriptase inhibitors

doi: 10.1093/jac/dkae383

Figure Lengend Snippet: Characteristics of patients according to the antiretroviral regimen composition

Article Snippet: D-dimer [Human D2D (D-Dimer) ELISA Kit], soluble ICAM-1 (sICAM-1) [Human ICAM-1/CD54 (intercellular adhesion molecule 1) ELISA Kit], soluble CD14 (sCD14) [Human sCD14 (Soluble Cluster of Differentiation 14) ELISA Kit] and soluble CD163 (sCD163) [Human sCD163 (Soluble Cluster of Differentiation 163) ELISA Kit] were measured by enzyme-linked immunosorbent assay (ELISA Kits, Elabscience Biotechnology Inc., USA) with an automated instrument (Dynex DS2 ® ELISA system).

Techniques: Cell Counting

Characteristics of patients according to the progression of cIMT during the 2 year follow-up

Journal: Journal of Antimicrobial Chemotherapy

Article Title: No accelerated progression of subclinical atherosclerosis with integrase strand transfer inhibitors compared to non-nucleoside reverse transcriptase inhibitors

doi: 10.1093/jac/dkae383

Figure Lengend Snippet: Characteristics of patients according to the progression of cIMT during the 2 year follow-up

Article Snippet: D-dimer [Human D2D (D-Dimer) ELISA Kit], soluble ICAM-1 (sICAM-1) [Human ICAM-1/CD54 (intercellular adhesion molecule 1) ELISA Kit], soluble CD14 (sCD14) [Human sCD14 (Soluble Cluster of Differentiation 14) ELISA Kit] and soluble CD163 (sCD163) [Human sCD163 (Soluble Cluster of Differentiation 163) ELISA Kit] were measured by enzyme-linked immunosorbent assay (ELISA Kits, Elabscience Biotechnology Inc., USA) with an automated instrument (Dynex DS2 ® ELISA system).

Techniques: Cell Counting

Patients’ characteristics according to the antiretroviral regimen composition after propensity score matching

Journal: Journal of Antimicrobial Chemotherapy

Article Title: No accelerated progression of subclinical atherosclerosis with integrase strand transfer inhibitors compared to non-nucleoside reverse transcriptase inhibitors

doi: 10.1093/jac/dkae383

Figure Lengend Snippet: Patients’ characteristics according to the antiretroviral regimen composition after propensity score matching

Article Snippet: D-dimer [Human D2D (D-Dimer) ELISA Kit], soluble ICAM-1 (sICAM-1) [Human ICAM-1/CD54 (intercellular adhesion molecule 1) ELISA Kit], soluble CD14 (sCD14) [Human sCD14 (Soluble Cluster of Differentiation 14) ELISA Kit] and soluble CD163 (sCD163) [Human sCD163 (Soluble Cluster of Differentiation 163) ELISA Kit] were measured by enzyme-linked immunosorbent assay (ELISA Kits, Elabscience Biotechnology Inc., USA) with an automated instrument (Dynex DS2 ® ELISA system).

Techniques: Cell Counting

Development of the IFNγ-driven sepsis (IDS) endotype in the discovery set . A) Bar graphs of 28-day mortality in patients with IFNγ more than 3 pg/ml and IFNγ 3 pg/ml or less. The p-value of comparison by the Fisher's exact test is provided. B) Distributions of the absolute count of HLA-DR receptors on CD45/CD14-monocytes in patients with IFNγ more than 3 pg/ml and IFNγ 3 pg/ml or less. Lines overlying the distributions represent medians and interquartile ranges. The p-value of comparison by the Mann–Whitney U test is provided. C) Distributions of sCD163 in patients with IFNγ more than 3 pg/ml and IFNγ 3 pg/ml or less. Lines overlying the distributions represent medians and interquartile ranges. The p-value of comparison by the Mann–Whitney U test is provided. D) Distributions of CXCL9 in survivors and non-survivors. This comparison involves only the patients with IFNγ levels more than 3 pg/ml. Lines overlying the distributions represent medians and interquartile ranges. The p-value of comparison by the Mann–Whitney U test is provided. Abbreviations: CI, confidence interval; IDS, IFNγ-driven sepsis; IFN, interferon; n, number of patients.

Journal: eBioMedicine

Article Title: Interferon-gamma driven elevation of CXCL9: a new sepsis endotype independently associated with mortality

doi: 10.1016/j.ebiom.2024.105414

Figure Lengend Snippet: Development of the IFNγ-driven sepsis (IDS) endotype in the discovery set . A) Bar graphs of 28-day mortality in patients with IFNγ more than 3 pg/ml and IFNγ 3 pg/ml or less. The p-value of comparison by the Fisher's exact test is provided. B) Distributions of the absolute count of HLA-DR receptors on CD45/CD14-monocytes in patients with IFNγ more than 3 pg/ml and IFNγ 3 pg/ml or less. Lines overlying the distributions represent medians and interquartile ranges. The p-value of comparison by the Mann–Whitney U test is provided. C) Distributions of sCD163 in patients with IFNγ more than 3 pg/ml and IFNγ 3 pg/ml or less. Lines overlying the distributions represent medians and interquartile ranges. The p-value of comparison by the Mann–Whitney U test is provided. D) Distributions of CXCL9 in survivors and non-survivors. This comparison involves only the patients with IFNγ levels more than 3 pg/ml. Lines overlying the distributions represent medians and interquartile ranges. The p-value of comparison by the Mann–Whitney U test is provided. Abbreviations: CI, confidence interval; IDS, IFNγ-driven sepsis; IFN, interferon; n, number of patients.

Article Snippet: Samples were transported into a central lab for the measurement of the following proteins: a) IFNγ, IP-10 (Diaclone, Besançon, France), CXCL9, interleukin (IL)-18 and soluble sCD163 (ELK Biotechnology, Denver, USA) with an enzyme immunosorbent assay.

Techniques: Comparison, MANN-WHITNEY